Relevance of exposure and disease

  • General Information of Study
    • Overview
      Name The Chinese National Twin Cohort(CNTR)
      Project Number CCC2017051703
      LI Liming
      Institutions Peking University
      GAO Wenjing
      Funding Specific Program of Public Farewell Industyr (201502006, 201002007) Key Program of Technic Research of Ministry of Education (310006) Natural Science Foundation of China (81573223m 81473041, 81202264) Program of Chinese Medical Foundation (01-746)
      Objectives Relevance of exposure and disease
      Start Date year 1999
      End Date year 2018
    • Study Design
      Number of Participants 48517 pairs of twins
      Age Range All ages
      Geographic Distribution Shandong, Zhejiang, Beijing, Shanghai, Jiangsu, Sichuan, Tianjin, Qinghai, Heilongjiang, Hebei, Yunnan
      General Information of Study Design and Sample Methods The volunteer registration system and sampling is not considered
      Inclusion Criteria Permanent local residents with clear consciousness who is collaborative in the survey. All ages, healthy or disabled, identical or non-identical, two members or one member of the twin can all participate in the baseline survey.
      Exclusion Criteria If one member of the twin is excluded, the twins are excluded.
    • Other Information
      Key Achievements Provide Chinese local evidence for the heredity grade of correlated characters of chronic diseases and DNA methylation.
      Marker Papers 1. Liao C, Gao W, Cao W, et al. Associations Between Obesity Indicators and Blood Pressure in Chinese Adult Twins [J]. Twin Res Hum Genet, 2017, 20(1):28-35. DOI: 10.1017/thg.2016.95.
      2. Wang B, Gao W, Li J, et al. Methylation loci associated with body mass index, waist circumference, and waist-to-hip ratio in Chinese adults: an epigenome-wide analysis [J]. Lancet, 2016, 388 Suppl 1:S21. DOI: 10.1016/S0140-6736(16)31948-1.
      3. Liao C, Gao W, Cao W, et al. The association of cigarette smoking and alcohol drinking with body mass index: a cross-sectional, population-based study among Chinese adult male twins [J]. BMC Public Health, 2016, 16:311. DOI: 10.1186/s12889-016-2967-3.
      4. Liao C, Tan Y, Wu C, et al. City Level of Income and Urbanization and Availability of Food Stores and Food Service Places in China [J]. PLoS One, 2016, 11(3):e0148745. DOI: 10.1371/journal.pone.0148745.
      5. Wang B, Gao W, Lv J, et al. Physical activity attenuates genetic effects on BMI: Results from a study of Chinese adult twins [J]. Obesity (Silver Spring), 2016, 24(3):750-756. DOI: 10.1002/oby.21402.
      6. Liu Q, Yu C, Gao W, et al. A co-twin control study on birth weight, overweight and obesity among children younger than 18 years old in China [J]. Chin J Epidemiol, 2016, 37(4):464-468. (in Chinese) Liu q, Yu C, Gao W, et al. Correlation analysis of birth weight and overweight/obesity of Chinese twins under 18 years old [J]. Chinese Journal of Epidemiology, 2016, 37(4):464-468. DOI: 10.3760/cma.j.issn.0254-6450.2016.04.005.
      7. Liao C, Gao W, Cao W, et al. Associations of Body Composition Measurements with Serum Lipid, Glucose and Insulin Profile: A Chinese Twin Study [J]. PLoS One, 2015, 10(11):e0140595. DOI: 10.1371/journal.pone.0140595.
      8. Liu Q, Yu C, Gao W, et al. Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample [J]. Twin Res Hum Genet. 2015, 18(5):571-580. DOI: 10.1017/thg.2015.63.
      9. Zhou B, Li L, Lv J, et al. Heritability of body mass index on Chinese adult twins from nine provinces/cities in China [J]. Chin J Epidemiol, 2015, 36(4):299-303. (in Chinese) Zhou B, Li L, Lv J, et al. Evaluation of the heredity degree of weight index of adult twin in 9 provinces (cities) in China [J]. Chinese Journal of Epidemiology, 2015, 36(4):299-303. DOI: 10.3760/cma.j.issn.0254-6450.2015.04.001.
      10. Wang B, Zhou B, Gao W, et al. The value of twin study in epigenetic research[J]. Chin J Epidemiol, 2015, 36(4):402-404. (in Chinese) Wang B, Zhou B, Gao W, et al. Value of twin in the study of epigenetics [J]. Chinese Journal of Epidemiology, 2015, 36(4): 402-404. DOI: 10.3760/cma.j.issn.0254-6450.2015.04.023.
      11. Liu Q, Yu C, Gao W, et al. Change trend of birth weight of twins in China, 1995-2012[J]. Chin J Epidemiol, 2015, 36(2):115-118. (in Chinese) DOI: 10.3760/cma.j.issn.0254-6450.2015.02.003. Liu Q, Yu C, Gao W, et, al. Analysis of change trend of birth weight of twin born between 1995-2012 in China [J]. Chinese Journal of Epidemiology, 2015, 36(2):115-118. DOI: 10.3760/cma.j.issn.0254-6450.2015.02.003.
      12. Wang B, Gao W, Yu C, et al. Determination of Zygosity in Adult Chinese Twins Using the 450K Methylation Array versus Questionnaire Data[J]. PLoS One, 2015, 10(4):e0123992. DOI: 10.1371/journal.pone.0123992.
      13. Zhou B, Gao W, Lv J, et al. Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together[J]. Behav Genet, 2015, 45(4):427-437. DOI: 10.1007/s10519-015-9711-0.
      14. Gao W, Zhou B, Cao W, et al. Utilizing the resource of twins reared apart: their distribution across nine provinces or cities of China[J]. Twin Res Hum Genet, 2015,18(2):210-216. DOI: 10.1017/thg.2015.9.
      15. Wang B, Liao C, Zhou B, et al. Genetic contribution to the variance of blood pressure and heart rate: a systematic review and meta-regression of twin studies[J]. Twin Res Hum Genet, 2015,18(2):158-170. DOI: 10.1017/thg.2015.8.
      Strength 1.As specifc group of people, twins as the cohort subject can be more recognized by the twins, which is an advantage to attract large quantity of twin vulenteers.
      2.Investigation of the correlation of heredity and environmental factor using the twin cohort has specific advantage that other population cohorts do not have and natural control is the primary advantage.
      Weakness 1. The extreme dispersibility of twin in population makes the organization and administration of twin cohort difficult.
      2. The cohor lacks stable funds and encourge mechanism.