Population that is occupational exposed to chromate is taken as the study object and that is not occupational exposed to chromate is included as the control. On the basis of environmental exposure and biological exposure evaluation, the exposure science techniques are applied to understand the effect of occupational chromate exposure on the metallomics, genetic damages, epigenetic modification and hereditary susceptibility with the expectation of evaluating the early health effect of chromate exposure, evidence-based health surveillance and explaining the carcinogenic mechanism of chemical cancerogen and provided scientific evidence for the treatment of environment contamination and health protection.

  • General Information of Study
    • Overview
      Name Occupational carcinogen chromate exposure cohort
      Project Number CCC2017071101
      Website None
      Investigators
      JIA Guang
      Institutions School of Public Health, Peking University
      Contacts
      HU Guiping
      Funding National Natural Science Foundation of China (81573118, 81273043, 81072281, 30571550)
      Objectives Population that is occupational exposed to chromate is taken as the study object and that is not occupational exposed to chromate is included as the control. On the basis of environmental exposure and biological exposure evaluation, the exposure science techniques are applied to understand the effect of occupational chromate exposure on the metallomics, genetic damages, epigenetic modification and hereditary susceptibility with the expectation of evaluating the early health effect of chromate exposure, evidence-based health surveillance and explaining the carcinogenic mechanism of chemical cancerogen and provided scientific evidence for the treatment of environment contamination and health protection.
      Start Date 2010.12
      End Date None
    • Study Design
      Number of Participants Exposure group (400 cases), control group (200 cases)
      Age Range 18-60 years old
      Geographic Distribution Central China area
      General Information of Study Design and Sample Methods Study of the whole population
      Inclusion Criteria 1. Those who have been working for at least a whole year in the factory
      2. Those who must have been worked for over 3 months on the current position
      3. The age should be 18-55 years old
      Exclusion Criteria 1. The study objects are patients of certain diseases like digestive tract disease, liver and kidny disease, diabetes, cardiovascular disease, tumor, immuno system disease like allergican aphylactic rhinitis and asthma.
      2. In the past three months, those who have taken nutritious supplementary (like 21 Super-Vita, dream ticket, iron preparation and zinc preparation), traditional Chinese medicine or other immunosuppressors.
      3. In the past three months, those who have been exposed to the radiation; those who have their hair permed or dyed or the home decoration has done.
    • Other Information
      Key Achievements Based on the environmental exposure and biological exposure of chromate monitore, the occupational exposure limit of chromate workplace suggested decreasing to 30 μg/m3 from the current 50 μg/m3; combined with the early health-effect indicators like blood routine, renal function, genetic damage, we propose that the occupational exposure limit of chromate is recommended to be 20 μg/L. In addition, studies have shown that the occupational exposure of chromate can cause changes of the metal in the peripheral blood; epigenetic modification has participated in the genetic damage of perepheral blood caused by the chromate.
      Marker Papers 1. Hu Guiping, Wang Tianjing, Liu Jiaxing,Chen Zhangjian, Zhong Lijun, Zhai Min, Jia Guang*. Serum Protein Expression Profiling and Bioinformatics Analysis in Workers Occupationally Exposed to Chromium (VI)[J]. Toxicol Lett, 2017, 277:76-83.
      2. Hu Guiping, Li Ping, Li Yang, Wang Tiancheng, Gao Xin, Zhang Wenxiao, Jia Guang*. Methylation levels of P16 and TP53 that are involved in DNA strand breakage of 16HBE cells treated by hexavalent chromium. [J]. Toxicol Lett. 2016, 249:15-21.
      3. Li Ping, Li Yang, Zhang Ji, Wang Zhiliang, Jia Guang*. Establishment of a reference value for chromium in the blood for biological monitoring among occupational chromium workers. Toxicol Ind Health, 2016, 32(10):1737-44. 4. Li Ping, Li Yang, Zhang Ji, Yu Shanfa, Wei Tong, Hu Xiao, Jia Guang*. Biomarkers for lung epithelium injury in occupational hexavalent chromium-exposed workers. J Occup Environ Med, 2015,57(4): e45-50.
      5. Li Yang, Li Ping, Yu Shanfa, Zhang Ji, Wang Tiancheng, Jia Guang*. miR-3940-5p associated with genetic damage in workers exposed to hexavalent chromium [J]. Toxicol Lett. 2014, 229(1):319-326.
      Strength 1. The exposure of occupational personnel is relatively stable with little mobility
      2. The extensive collaboration and alliance of tackling the key problems by Peking University and the cooperating organization (like enterprise, administration department of the government, health service department, etc.) is realized, as well as the multi-layers, multi-disciplinary, and multi-functional cooperation of "production, learning, research and application"

      Weakness 1. The sample size of the control population is relatively small
      2. The morbidity of the outcome is relatively low