To evaluate the effect of supplementing micronutrient complex during pregnancy on the adverse pregnant outcome like perinatal infant death
General Information of Study
Name Micronutrient Supplementation and Pregnancy Outcomes: Double-Blind Randomized Controlled Trial in China
Project Number CCC2017072101 Website None Investigators Institutions Institute of Reproductive Health, Peking University Contacts Funding US Centers for Disease Control and Prevention Objectives To evaluate the effect of supplementing micronutrient complex during pregnancy on the adverse pregnant outcome like perinatal infant death
Start Date May, 2006 End Date December, 2011
Number of Participants The objects were assigned into 3 interference group: folic acid group, folic acid+iron group and folic acid+iron+other micronutrient complex group with 6261, 6252 and 6262 people in each group Age Range ≥20 years old Geographic Distribution 5 counties in Hebei General Information of Study Design and Sample Methods Not sampled Inclusion Criteria Primipara; ≥20 years old; gestational weeks< 20 weeks; have not taken other micronutrients other than folic acid in the past 6 months; hemoglobin≥100 g/L
Key Achievements Supplementary of folic acid+iron or micronutrient complex at the first 20 weeks of pregnancy cannot decrease the risk of perinatal infant death but can decrease the risk of anemia during pregnancy compared with simple supplementary of folic acid. Marker Papers 1. Liu JM, Mei Z, Ye R, Serdula MK, Ren A, Cogswell ME. Micronutrient supplementation and pregnancy outcomes: double-blind randomized controlled trial in China. JAMA Intern Med 2013; 4: 276-82.
2. Mei Z, Serdula MK, Liu JM, et al. Iron-containing micronutrient supplementation of Chinese women with no or mild anemia during pregnancy improved iron status but did not affect perinatal anemia. J Nutr 2014; 6: 943-8.
3. Mei Z, Li H, Serdula MK, et al. C-reactive protein increases with gestational age during pregnancy among Chinese women. Am J Hum Biol 2016; 4: 574-9.
4. Wang L, Mei Z, Li H, Zhang Y, Liu J, Serdula MK. Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial. Br J Nutr 2016; 4: 644-9.
5. Li Z, Mei Z, Zhang L, et al. Effects of Prenatal Micronutrients Supplementation on Spontaneous Preterm Birth: Double-Blind Randomized Controlled Trial in China. Am J Epidemiol 2017.
Strength This is the largest study based on the personal randomized grouping in the field; the venous blood from a total of over 800 pregnant women has been collected; a follow-up is conducted for the children delivered by the women who have participated in this program (about 3 years old) Weakness None
General Information of Baseline Investigation
Variables of Baseline Investigation
General Information of Follow-up Investigation
Variables of Follow-up Investigation