To evaluate the effect of supplementing micronutrient complex during pregnancy on the adverse pregnant outcome like perinatal infant death

  • General Information of Study
    • Overview
      Name Micronutrient Supplementation and Pregnancy Outcomes: Double-Blind Randomized Controlled Trial in China
      Project Number CCC2017072101
      Website None
      Investigators
      LIU Jianmeng
      Institutions Institute of Reproductive Health, Peking University
      Contacts
      LI Hongtian
      Funding US Centers for Disease Control and Prevention
      Objectives To evaluate the effect of supplementing micronutrient complex during pregnancy on the adverse pregnant outcome like perinatal infant death
      Start Date May, 2006
      End Date December, 2011
    • Study Design
      Number of Participants The objects were assigned into 3 interference group: folic acid group, folic acid+iron group and folic acid+iron+other micronutrient complex group with 6261, 6252 and 6262 people in each group
      Age Range ≥20 years old
      Geographic Distribution 5 counties in Hebei
      General Information of Study Design and Sample Methods Not sampled
      Inclusion Criteria Primipara; ≥20 years old; gestational weeks< 20 weeks; have not taken other micronutrients other than folic acid in the past 6 months; hemoglobin≥100 g/L
      Exclusion Criteria
    • Other Information
      Key Achievements Supplementary of folic acid+iron or micronutrient complex at the first 20 weeks of pregnancy cannot decrease the risk of perinatal infant death but can decrease the risk of anemia during pregnancy compared with simple supplementary of folic acid.
      Marker Papers 1. Liu JM, Mei Z, Ye R, Serdula MK, Ren A, Cogswell ME. Micronutrient supplementation and pregnancy outcomes: double-blind randomized controlled trial in China. JAMA Intern Med 2013; 4: 276-82.
      2. Mei Z, Serdula MK, Liu JM, et al. Iron-containing micronutrient supplementation of Chinese women with no or mild anemia during pregnancy improved iron status but did not affect perinatal anemia. J Nutr 2014; 6: 943-8.
      3. Mei Z, Li H, Serdula MK, et al. C-reactive protein increases with gestational age during pregnancy among Chinese women. Am J Hum Biol 2016; 4: 574-9.
      4. Wang L, Mei Z, Li H, Zhang Y, Liu J, Serdula MK. Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial. Br J Nutr 2016; 4: 644-9.
      5. Li Z, Mei Z, Zhang L, et al. Effects of Prenatal Micronutrients Supplementation on Spontaneous Preterm Birth: Double-Blind Randomized Controlled Trial in China. Am J Epidemiol 2017.
      Strength This is the largest study based on the personal randomized grouping in the field; the venous blood from a total of over 800 pregnant women has been collected; a follow-up is conducted for the children delivered by the women who have participated in this program (about 3 years old)
      Weakness None