Through the long-term follow-up of patients with diabetic nephropathy in Kailuan study and the establishment of biological specimen bank, this project studies the occurrence, development, prognosis and biomarkers of diabetic nephropathy, in order to reveal the development mechanism of diabetic nephropathy in China. It also provides an useful attempt to study the chronic disease management pattern in patients with diabetic nephropathy in China.

  • General Information of Study
    • Overview
      Name Incidence,development and prognosis of diabetic kidney disease in China. (INDEED study)
      Project Number CCC2017091801
      Website None
      Investigators
      ZHAO Minghui
      ZHANG Luxia
      CHEN Min
      Institutions Peking University First Hospital
      Contacts
      WANG Jinwei
      Funding The 13th Five-Year Plan Project on Major Chronic Disease, Item Number 2016YFC1305400
      Objectives Through the long-term follow-up of patients with diabetic nephropathy in Kailuan study and the establishment of biological specimen bank, this project studies the occurrence, development, prognosis and biomarkers of diabetic nephropathy, in order to reveal the development mechanism of diabetic nephropathy in China. It also provides an useful attempt to study the chronic disease management pattern in patients with diabetic nephropathy in China.
      Start Date April, 2016
      End Date June, 2021
    • Study Design
      Number of Participants 8,000
      Age Range ≥18 years old
      Geographic Distribution Tangshan in Hebei province
      General Information of Study Design and Sample Methods All diabetic patients included in the Kailuan study with test results in 2010 were selected in the INDEED study.
      Inclusion Criteria All patients with diabetes in Kailuan study: 1. Previous history of diabetes and/or medical history on hypoglycemic drugs; 2. Fasting blood glucose ≥7.0mmol/l. Reference criteria: Guidelines for type 2 diabetes of China (2013)
      Exclusion Criteria None
    • Other Information
      Key Achievements None
      Marker Papers Yang, Y. Z., Wang, J. W., Wang, F., Wu, Y. T., Zhao, H. Y., & Chen, M., et al. (2017). Incidence, development, and prognosis of diabetic kidney disease in china: design and methods. Chinese Medical Journal, 130(2), 199-202.http://www.cmj.org/article.asp?issn=0366-6999;year=2017;volume=130;issue=2;spage=199;epage=202;aulast=Yang
      Strength Based on the mature and well-managed cohort in Kailuan study. Since the subjects were staff in Kailuan Group Company Limited, there was low in loss of follow-up rate. In addition, their previous diagnosis and treatment, and endpoint events were all recorded in the health insurance system.
      Weakness 1.All included group in INDEED study were the employees of Kailuan Group. They were all from North China.
      2. Most (80%) were male.