To estimate the prevalence, incidence, burden and risk factors of progression and prognosis of osteoarthritis in China, and provide data-based support for the management and primary care of osteoarthritis.

  • General Information of Study
    • Overview
      Name A multicenter cohort study on the incidence, progression and prognosis of osteoarthritis in China
      Project Number CCC2018040101
      Website N/A
      Investigators
      Lin Jianhao
      Institutions Peking University People's Hospital
      Contacts
      Liu Qiang
      Funding Beijing Municipal Science & Technology Commission, D121100004212003
      Objectives To estimate the prevalence, incidence, burden and risk factors of progression and prognosis of osteoarthritis in China, and provide data-based support for the management and primary care of osteoarthritis.
      Start Date August, 2005
      End Date December, 2022
    • Study Design
      Number of Participants 5222
      Age Range 50 years and older
      Geographic Distribution Beijing, Inner Mongolia, Henan and Ningxia
      General Information of Study Design and Sample Methods Compact segment sampling
      Inclusion Criteria Permanent residents aged 50 years and older
      Exclusion Criteria People with self-reported rheumatoid arthritis, cerebrovascular disease
    • Other Information
      Key Achievements The prevalence of osteoarthritis was higher compared with western countries, causing substantial physical disability. The burden of osteoarthritis was heavier in rural areas and Southwestern region. Symptomatic knee osteoarthritis was associated with an increased all-cause mortality, potentially mediated through impaired physical diasbility and its interplay with cardiovascular diseases. Therefore, osteoarthritis is a remarkable threat to longevity and quality of life for old people.
      Marker Papers 1. Kang X, Fransen M, Zhang Y, Li H, Ke Y, Lu M, Su S, Song X, Guo Y, Chen J, Niu J, Felson D, Lin J. The high prevalence of knee osteoarthritis in a rural Chinese population: the Wuchuan osteoarthritis study. Arthritis Rheum. 2009;61(5):641-7. ( SCI IF=7.871,他引29次)
      2. 林剑浩,康晓征,李虎,柯岩,鲁明,郭勇,陈捷 武川县农村居民膝关节骨关节炎患病率调查 中华骨科杂志 2009, 29(10)
      3. 林剑浩,杨艺,康晓征,李虎 中国内蒙古武川地区50岁以上中老年人髌股关节炎发病率及性别年龄分布特征研究,中华风湿病学杂志 2010,14(3):161-64
      4. Lin J, Fransen M, Kang X, Li H, Ke Y, Wang Z, Zhang Y, Su S. Marked disability and high use of nonsteroidal anti-inflammatory drugs associated with knee osteoarthritis in rural China: a cross-sectional population-based survey. Arthritis Research & Therapy 2010,12:R225. (SCI IF=4.117,他引7次)
      5. Lin J, Li R, Kang X, Li H. Risk factors for radiographic tibiofemoral knee osteoarthritis: the Wuchuan osteoarthritis study. Int J Rheumatol. 2010:385826. Epub 2010 Dec 28.
      6. Liu Q, Niu J, Huang J, Ke Y, Tang X, Wu X, Li R, Li H, Zhi X, Wang K, Zhang Y, Lin J. Knee Osteoarthritis and All-cause Mortality: The Wuchuan Osteoarthritis Study. Osteoarthritis Cartilage. 2015 Mar 25.
      7. 林剑浩,康晓征,Marlerie Fransen,李虎,柯岩,王志强,Yuqing Zhang, Steve Su。 与膝关节疼痛相关的功能障碍及常规治疗措施的调查 中华医学杂志 2010, 90(21)
      8. Wang B, Liu Q*, Lin J, et.al, Valgus malalignment and prevalence of lateral compartmental radiographic knee osteoarthritis (OA): the Wuchuan OA Study, International Journal of Rheumatic Diseases, 2017 Apr 26
      9. Liu Q, Zhang Y, Lin J, et.al, Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study, Scientific Reports, 7: 3309 • June 2017
      10. Xing, D. et al. Osteoarthritis and all-cause mortality in worldwide populations: grading the evidence from a meta-analysis. Scientific reports 6, 24393, doi:10.1038/srep24393 (2016). (SCI IF=5.228)
      Strength 1. Population-based study;
      2. Standard study protocol and strict quality control
      Weakness Uneven interval of follow-up