The purpose is to understand the general situation of Mongolian teenagers'myopia and to answer the question whether the unique biological and cultural characteristics of Mongolian are protective factors to slow down the occurrence and development of myopia. Through the baseline survey and three-year follow-up monitoring, the cohort study was completed, and the results of the prevalence, risk factors and ethnic differences of Mongolian adolescents were obtained. The natural course of myopia and its occurrence and development were discussed. The epidemiological evidence was provided for grasping the opportunity of myopia prevention and control and screening the methods of myopia prevention and control. It provides a theoretical basis for policy-making of health institutions.

  • General Information of Study
    • Overview
      Name The Gobi Desert Children Eye Study
      Project Number CCC2018111201
      Website NA.
      Investigators
      Dan Zhu
      Institutions Affiliated Hospital of Inner Mongolia Medical University
      Contacts
      Dan Zhu
      Funding Inner Mongolia science and technology department science and technology project, Project No. kjt15sf18
      Objectives The purpose is to understand the general situation of Mongolian teenagers'myopia and to answer the question whether the unique biological and cultural characteristics of Mongolian are protective factors to slow down the occurrence and development of myopia. Through the baseline survey and three-year follow-up monitoring, the cohort study was completed, and the results of the prevalence, risk factors and ethnic differences of Mongolian adolescents were obtained. The natural course of myopia and its occurrence and development were discussed. The epidemiological evidence was provided for grasping the opportunity of myopia prevention and control and screening the methods of myopia prevention and control. It provides a theoretical basis for policy-making of health institutions.
      Start Date Dec 2013
      End Date Dec 2016
    • Study Design
      Number of Participants 1565
      Age Range 7-21years
      Geographic Distribution Alxa League, Ejinaqi, the Inner Mongolia Autonomous Region
      General Information of Study Design and Sample Methods Cluster sampling
      Inclusion Criteria A total of 1911 students from all three schools in Ejina.
      Exclusion Criteria None
    • Other Information
      Key Achievements The total number of students examined in this study was 1565/1911, and the response rate was 81.9%. The average age of the students examined was 11.8 + 3.5 years, and the age range was 7-21 years. Among them, 746 (51.0%) were boys, 1127 (77.0%) were Han students, and 336 (23.0%) were Mongols, Huis, Manchus and Tibetans. The prevalence of diopter (-6.00D) was 2.9 (-0.4%); the prevalence of diopter (-8.00D) was 0.7 (-0.2%); the prevalence of diopter (-6.00D) was 0.9%, 3.4% and 8.5% in the age group of 7, 12 and 18, respectively (P < 0.001); school classification was correlated (Han Nationality School > ethnic school, 3.2% /0.9%, P = 0.04); gender was not correlated (P = 0.98). There was a significant negative correlation between IOP and age in Ejina adolescents; the correlation between IOP and blood pressure in adolescents was consistent with that of previously reported adults; the correlation between myopic refractive error and IOP was the lowest in multiple regression analysis; previous studies showed that BMI was positively correlated with IOP, which was intraocular pressure. Elevated independent risk factors. The average subfoveal choroidal thickness in Ejina adolescents was 282 +49 micron in the right eye and 281 +51 micron in the left eye, with no significant difference. The distribution of choroidal thickness was 1 000 micron from the temporal side of the fovea, 1 500 micron from the temporal side of the fovea, 1 000 micron from the nasal side of the fovea, 2 500 micron from the nasal side of the central fovea. Subfoveal choroidal thickness increased with age, and decreased with age after 11 years old. After excluding age, subfoveal choroidal thickness was mainly related to high myopia, but not to body mass index, race and ocular perfusion pressure. Like adults, RNFL thickness in Ejina adolescents is a parallel bimodal structure; RNFL thickness decreases with myopic refraction, and RNFL thickness in girls is higher than that in boys; RNFL thickness in school-age children does not decrease with age; age-related RNFL and retinal ganglion cell axon loss Failure may occur at a larger age.
      Marker Papers (1)Zhu, Dan; Wang, Yan; Zheng, Yan Fei; Yang, Da Yong; Guo, Kai; Yang, Xian Rong; Jing, Xin Xia; Wong, Ian Y.; You, Qi Sheng; Tao, Yong; Jonas, Jost B., Choroidal thickness in school children: The Gobi Desert Children Eye Study, PLOS ONE, 2017.6.15, 12(6)
      (2)Zhu, Dan; You, Qisheng; Tao, Yong; Jonas, Jost B., Choroidal Thickness in School Children: The Gobi Desert Children Eye Study, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA, 2016.5.1-2016.5.5
      (3)Dan Zhu(#); Da-Yong Yang; Yuan-Yuan Guo; Yan-Fei Zheng; Jun-Lian Li; Bin Wang; Yong Tao; Jost B Jonas, Intracameral Interleukin 1beta, 6, 8, 10, 12p, Tumor Necrosis Factor alpha and Vascular Endothelial Growth Factor and Axial Length in Patients with Cataract., PLos One, 2015, 10(2): e0117777~e0117777
      (4)Kai Guo(#); Da Yong Yang,; Yan Wang; Xian Rong Yang; Xin Xia Jing; Yuan Yuan Guo; Zhu Dan(*); Qi Sheng You(*); Yong Tao; Jost B Jonas(*), Prevalence of Myopia in School Children in Ejina. The Gobi Desert Children Eye Study., Investigative Ophthalmology & Visual Science, 2015.1.27, 1(1)
      (5)Da Yong Yang(#); Kai Guo; Yan Wang; Yuan Yuan Guo; Xian Rong Yang; Xin Xia Jing; Hai Ke Guo; Yong Tao; Dan Zhu; Jost B Jonas, Intraocular pressure and associations in children. The Gobi Desert Children Eye Study. , PLos One, 2014, 9(10): e109355~e109355
      Strength 3 years' follow-up, Mongolian,adolescent myopia
      Weakness Remote and selective offset